Thorazine (Chlorpromazine)

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MENTAL HEALTH: TREATING SCHIZOPHRENIA
Around the mid-1950s, doctors discovered drugs that control the dopamine system and lower its activity. The best known of these is chlorpromazine (trade name: Thorazine). It doesn’t cure schizophrenia, but it lessens the hallucinations and delusions. However, chlorpromazine slows the patient down, sometimes creating a slow-moving, slow-talking zombie effect. In a few patients the drug produces involuntary movements of the lip, tongue, and limbs. Usually, the movements stop if medication is reduced or stopped, but in a few patients this doesn’t help. (Some studies show that in some types of schizophrenia, lithium salts can quiet the manic or excited phases. The studies are just now defining exactly who is helped by this drug.)
These drugs are the only real treatments doctors have. In the 1920s, they tried tooth removal to treat schizophrenia; in the 1930s, injections of horse serum; in the 1940s, enemas. All failed. In the 1950s, big doses of vitamins were tried, and the megavitamin trend persists, even though the American Psychiatric Association declared in 1971 that there was no evidence from studies that vitamin therapy did any good. Dr. Morris Lipton of the University of North Carolina Medical School at Chapel Hill headed the original studies and says nothing since has changed this.
For about 40 percent of schizophrenics, the brain drugs don’t work. Dr. Friedhoff says that, although the drugs lower the dopamine levels as far as possible, the brain can’t function properly.
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