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ECZEMA TREATMENT: HOW EVENING PRIMROSE OIL HELPS
Patients with atopic eczema show some of the signs of essential fatty acid deficiency. But in fact their blood has been found to have above-average levels of linoleic acid and also of alpha-linolenic acid. So the problem is not that people with atopic eczema are eating too little of the foods containing the parent essential fatty acids. Rather, there seems to be some problem in using these fatty acids. They are not being metabolized properly.
The blood of someone with atopic eczema is typically very low in the metabolites of linoleic acid and alpha-linolenic acid, which indicates that there is probably- an enzyme block stopping the conversion of these essential fatty acids.
All the studies done so far agree that people with atopic eczema have below-normal levels of GLA, DGLA, AA, PGE1 and the metabolites of alpha-linolenic acid. The enzyme delta-6-desaturase is needed to get from linoleic acid to the next step and from alpha-linolenic acid to the next step.
Evening primrose oil completely by-passes this enzyme block by starting at the next stage in the metabolic pathway of the linoleic acid family. (It has no effect on the alpha-linolenic family. Fish oils should also be taken to help correct the low level of metabolites of the alpha-linolenic acid family.)
Various studies have been done to see what happens to the fatty acid profile of the blood after people with atopic eczema have been taking evening primrose oil. Overall, the results are that evening primrose oil can go some way to correcting this abnormal blood profile and make it more normal.
No one knows exactly why the delta-6-desaturase enzyme may be defective. There are many possible reasons for this, including a minor abnormality in the protein structure of the enzyme or an abnormality of co-factors.
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