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NUTRIENTS AND THEIR UTILIZATION: METABOLISM
Metabolism is an inclusive term that describes all the changes that take place in the body. Anabolism is a more specific term that is used to indicate the building up of complex substances from simpler substances. Building new bone, or hemoglobin, or muscle tissue would be examples of anabolism.
Catabolism by contrast, refers to the breaking down of complex substances into simpler substances. The breakdown of glucose or fatty acids to yield energy is an example of catabolism.
The terms “dynamic equilibrium” and “homeostasis” are sometimes used to indicate that the processes of anabolism and of catabolism are continuously taking place and that the one is equal to the other. In growing children, during pregnancy, and during recovery from illness the processes of anabolism are greater than those of catabolism. On the other hand, excessive catabolism takes place with high fever, during acute illness, following surgery, fractures, and burns, or when certain hormones are produced in excessive amounts by the body.
The innumerable reactions in metabolism require the activity of enzymes. Many of these enzymes require another substance called a coenzyme in addition to the protein. One of the important functions of vitamins and certain mineral elements is to act as coenzymes.
Hormones maintain a system of checks and balances on metabolism. To name just a few: thyroxin, produced by the thyroid gland, regulates energy metabolism; insulin, produced in the pancreas, controls the level of the blood sugar; an adrenal hormone controls the amount of sodium retained or excreted.
In addition to (1) ingestion, (2) digestion, and (3) absorption, metabolism includes these categories.
4. Transportation of the nutrients to the cells where they are needed and of the wastes to the organs of excretion is the function of the blood circulation.
5. Respiration. In the lungs oxygen is taken into the blood so that the nutrients may be combined with oxygen (oxidized). Through the lungs carbon dioxide is given off as a waste.
6. Utilization. Within every cell are found hundreds of enzymes that bring about the appropriate functions in terms of energy, building or maintenance, and regulation. In a complex series of steps glucose combines with oxygen to release the energy for the body’s work. Fats, likewise, are oxidized for energy. Carbohydrates and fats are also stored as potential energy in the form of adipose tissue. Amino acids are used to build new cells, to form hormones, or enzymes, or as a source of energy. Mineral elements enter into the structure of the cell or into any one of many regulatory activities.
7. Excretion of wastes is accomplished by the kidney, which removes nitrogenous wastes, water, mineral salts, and excess water-soluble vitamins; by the bowel, which eliminates indigestible fiber, bile pigments, cholesterol and other products of metabolism, and bacterial wastes; by the skin, through which water, mineral salts, and some nitrogenous wastes are removed; and by the lungs, which remove carbon dioxide and water.
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