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Actigall (Ursodiol, Ursodeoxycholic)

Actigall (Ursodiol, Ursodeoxycholic)


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Other names: Urso
Actigall (Ursodiol, Ursodeoxycholic)
DIGESTION: SALIVARY GLANDS
The ones which force themselves most on our attention are the salivary glands of the mouth. You know that they are big enough to make a lot of fluid. But all along the canal are innumerable minute ones. Many of these secrete mucus, which lubricates. The others secrete “enzymes.” Enzymes are substances indispensable to the chemical reactions of the body. They would seem to be practically infinite in number and we know of most of them only by the results which they accomplish. They will be discussed later when we come to vitamins and hormones, the three being said to be one family.
Some of these enzymes have been identified and collected and occur in large amounts. The digestive enzymes, of which I have seen eighteen listed, are in this class. A few are well known: ptyalin of the saliva which changes starch to sugar is one. Perhaps the best known is pepsin of the gastric juice which certainly in my younger days everybody knew about. Every family bought it at the drugstore or got it in chewing gum. We were told that it came from the stomachs of hogs and digested protein. All of us medical students knew of the euphonious trio, trypsin, steapsin, and amylopsin, which comes from the pancreas and which transforms proteins, fats, and starches, respectively.
Although there is ptyalin in the saliva and it helps to digest starch, the chief use of the saliva is undoubtedly to soften food and make it easy to swallow. Several pints may be secreted daily. Americans apparently have plenty of saliva – at any rate, they have led the world in spitting, as has been commented on by English travelers. Mrs. Trollope in 1830 was disgusted with this habit; and later Charles Dickens, in his notes on his American tours, complained that Americans spat before him. Nowadays our supremacy in gum chewing, which, of course, keeps saliva flowing, makes several pints seem a reasonable figure.
Saliva is secreted by several sets of glands, the parotids in front of the ears being much the larger. I know not why mumps, or epidemic parotitis, which is so remarkably infectious, has a predilection for these glands. Neither do I know why in adult males the disease so often jumps to the testicles, often causing atrophy here. One of my internist friends told me that in the First World War the sickest patients he saw were those with mumps. For these reasons, I am inclined to think that one might find it the course of wisdom to let one’s children have the mumps, as the disease is mild in youth.
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