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Other names: Nimodipine

RISK FACTORS FOR HEART ATTACKS: HUMAN BALANCE SHEET
In one sense there is no mystery about obesity. In another there are real problems: in particular, why is it some people are especially prone to be overweight, and why is it this is sometimes so difficult to treat?
We get energy almost entirely from oxidizing (burning) food. The energy is measured in Calories or – if we are young enough -in joules. This energy is used in physical work, in the work of breathing, circulating the blood, keeping an upright posture. Some is needed to keep us warm, but we ‘waste’ a good deal of energy as heat, just as steam and petrol engines do. We also use energy in manufacturing complex substances such as proteins and fat, especially during growth but also throughout life.
Primitive man laid down fat (i.e. adipose tissue) in the body to aid in survival. Fat is really stored energy; when food supplies fall short of needs we rapidly come to depend on this fat, mobilizing it and using it as fuel for muscles, heart, liver and other organs. When energy intake is greater than energy needs, the fat stores in adipose tissue increase. If this goes on for long enough, we become obese.
Is there any other way in which fat stores increase? The answer -as nearly a certain truth as any in science – is ‘no’. To explain this we must recall some brilliant research which took place as long ago as 1880-1910. The great physiologists Rubner in Germany and Atwater, Benedict and Rosa in the U.S.A. were measuring the amount of energy needed by animals and man, and the amount they spent. Atwater built a heat-insulated room, in which a man could live for days. This was a calorimeter – exactly analogous to the little ones sometimes used at school. The man’s output of heat energy could be measured with amazing accuracy; other forms of energy loss were measured too. An energy balance sheet was drawn up with these measurements as ‘expenditure’; the ‘income’ was chiefly the energy derived from food.
Income and expenditure were found to balance very exactly indeed. This remained true when the man in the calorimeter took exercise: the mechanical work had to be added in to the balance sheet. Hence the energy spent was almost exactly the same as the energy consumed. In the language used by physicists, man conforms with the first law of thermodynamics: he can neither create nor destroy energy.
This means that the energy required to accumulate fat (i.e. to become obese) must be obtained from food. To be exact, weight gain only occurs when we eat more food energy than we spend. This is a second inescapable truth. It does not mean that every fat person eats large amounts of food; it does mean that obesity results from eating in excess of one’s needs.
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