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HOW EVENING PRIMROSE OIL MAY BE WORKING IN CANCER
The active ingredient in evening primrose oil is gammalinolenic acid (GLA), and it is the GLA which gives the oil its cancer-controlling properties. It maybe working in three different ways:
1. Lipid peroxides. What the researchers have found is that when human cancer cells are exposed to polyunsaturated fatty acids in the laboratory, the cells generate large amounts of substances called lipid peroxides, and die.
Several different PUFAs have been tried to see which one is the most effective. GLA seems to be the best PUFA – it is highly toxic to malignant cells, but has no toxic effects whatsoever on normal cells.
It is now known that the majority of human and animal cancers contain low levels of lipid peroxides. There is evidence that lipid peroxides play a role in regulating cell division. In most cancers, the reason for the low levels of lipid peroxides seems to be a low concentration of PUFA substrate, which is needed for the formation of peroxide.
This may on the face of it seem paradoxical, because peroxides have a reputation for always being harmful. However, it now seems as though lipid peroxides, although indeed harmful in some situations, may be physiological regulators of cell division.
Some capsules of evening primrose oil contain Vitamin E as an anti-oxidant. However, studies have shown that Vitamin E in fact inhibits the toxic effects of GLA on malignant cells, so the best treatment for cancer would be large doses of evening primrose oil without the Vitamin E. Ideally, fish oils should also be taken. New clinical trials on cancer are using Efatnol Marine, instead of Efamol on its own.
2. It by-passes the delta-6-desaturase enzyme block. Cancer is a known blocking agent of the metabolic pathway of linoleic acid. This block occurs at the first step, between linoleic acid and gammalinolenic acid, by inhibiting the delta-6-desaturase enzyme. The GLA in evening primrose oil by-passes this block by starting at the second stage in the metabolic pathway This means that GLA can convert to DGLA and then to prostaglandin El without hindrance.
3. Prostaglandins. Another way in which polyunsaturated fatty acids might be controlling cancer cells is by being converted into prostaglandins. Prostaglandins derived from PUFAs may inhibit the proliferation of human and animal tumour cells, and reverse transformed cells.
Originally it was thought that it was only PGE1 which had anti-cancer properties, but it now seems that other prostaglandins are important too.
It must be stressed that all the above studies are preliminary, and although major clinical trials are planned, there are no results to date.
However, evening primrose oil is already widely used by alternative health centers and practitioners, such as the Bristol Cancer Help Centre, for patients with cancer. In these cases it is used as part of a whole treatment programme, often involving several nutrients and a fundamental change of diet.
It must be emphasized that people with cancer should not treat themselves, but should always seek the advice of a qualified practitioner.
The studies with GLA are exciting, but the situation at the moment is that no double-blind trial has yet shown it to be effective. Until such trials are done, anyone with cancer taking evening primrose oil can only hope it will help them.
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