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STAGE THREE OF STRESS BREAKDOWN: DIFFICULTIES IN FINDINGS AND STUDIES
It is very difficult to find out what happens exactly in the brain at the cellular level
While scientists now understand a great deal about the brain, and while our knowledge of brain structure and function is expanding at an increasingly rapid rate, there are major problems in trying to work out how the individual cells and cell groups are affected by excessive stress.
The brain is a complex, living organ, encased in a thick bony box, the skull; there is almost no way we can examine it closely without interfering with its function. Therefore, although we know a great deal about the structure of the brain, which we’ve learned from cutting it up and examining it under microscopes, we don’t know as much about the behaviour of cells in the normal functioning brain.
The difficulty of studying chemical changes in the normal functioning brain
If we wanted to study how certain types of brain stimulation might change the levels of neuro-transmitter chemicals in the brain, we are immediately hampered by the fact that the brain is full of enzymes, whose job it is to destroy the neurotransmitter chemicals as soon as they are produced and have done their job of firing off the next neuron.
Therefore, in order to study changes in these neuro-transmitter chemicals occurring under conditions of high stress when the brain’s cells are over-stimulated, we would need to stop enzyme activity the moment that the over-stimulation occurred. In the laboratory, this would probably mean we would have to stimulate the brain, then immediately plunge it into liquid nitrogen to freeze it instantly, before cutting the brain into pieces and examining it.
Of course, doing something like this is totally out of the question when we are trying to learn something about the way human brain cells respond to over-stimulation; therefore much of what we believe about brain function is often in the form of workable theories, which persist until a better theory comes along.
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