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Other names: Brethaire

NEW ADVANCES STOPPING A STROKE: CHEMICAL/DRUG RESEARCH
When an artery bursts or is clogged, it can’t supply the brain cells with blood, and they die. The injured and dying cells then emit substances that spread the injury to a widening circle of brain cells. Release of these substances allows the entry of excess calcium into the cells, followed by the entry of water, which bloats and destroys the cells. Chemical compounds to reduce the risk to brain cells during stroke are now being tested for human use. They would protect the cells from being flooded with water in this deadly process.
Brain scientists also are testing many chemicals for their ability to dissolve blood clots and stop a stroke in progress. These include streptokinase, an enzyme from bacteria, and TPA, a chemical found in tiny amounts in human blood. Studies show that they destroy clots in the coronary arteries. There is some proof that these chemicals destroy clots in brain arteries.
An experimental anticoagulant called Ancrod comes from the venom of Malaysian pit vipers. It thins the blood, breaks up clots, and has been tested on about 500 persons with some success.
In addition, researchers are focusing on ways to prevent clot formation. Blood clots in the coronary arteries produce heart attacks. Antiplatelet (blood-thinning) drugs, including aspirin and warfarin, are being tested on a large scale to see which ones help prevent stroke. If you have suffered a stroke, the chances are that you will have another. Treatment with blood thinners can extend the life expectancy of stroke patients.
Aspirin therapy – depending on the patient and the dosage – has been found to stop clotting. If you are 50 or older, researchers urge you to consult with your physician about aspirin therapy to help prevent stroke or heart attack.
Warfarin, a prescription drug for humans, is a blood-thinning chemical. It was long known as an ingredient in rat poison. When used to prevent stroke, it requires careful management, including monthly blood tests and adjustments of the dosage, as its effects vary with age.
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